China developed a two-photon-stimulated emission loss (STED) microscope

[ Instrument Network Instrument Development ] Recently, under the support of the national key research and development program “Digital Diagnostic Equipment R&D”, Suzhou Guoke Medical Technology Development Co., Ltd., Jilin Yatai Biopharmaceutical Co., Ltd., Institute of Physics, Chinese Academy of Sciences, etc. The key research and development of digital diagnosis and treatment (project name: two-photon-stimulated emission loss (STED) composite microscope) jointly undertaken by many units has made important progress, and successfully developed the first two-photon-STED composite microscope prototype at home and abroad. Meet the project requirements. The project team completed the independent research and development of the core components in the microscope system, and successfully developed core components such as large area array CMOS cameras with independent intellectual property rights and large working distance large numerical aperture objective lenses, which broke the monopoly of foreign related products to China.

The first two-photon-STED composite microscope prototype at home and abroad

In today's biology and basic medicine research, super-resolution optical microscopy plays a vital role. Super-resolution micro-optical imaging is an important means to obtain original research results.

In the two-photon-STED imaging technology, relatively early in foreign countries, scientific research institutions in Germany, Canada, France, Italy and other countries have successfully built a two-photon-STED imaging experimental system; Later, the current two-photon STED imaging technology is still in the laboratory research stage, and there is no corresponding product in the world.

Therefore, the successful development of the two-photon-stimulated emission loss (STED) composite microscope is of great significance to meet the customized needs of cutting-edge basic research such as biomedicine in China, to enhance the innovation capability and to promote the upgrading of the microscope industry in China.

(Original title: China successfully developed a two-photon-stimulated emission loss (STED) composite microscope)